Ponce de Leon was the governor of Puerto Rico. Due to political intrigue within the Spanish Empire, he was encouraged to explore a new "island" rumored to be to the Northwest. On March 4th, 1513, he embarked on an expedition that he financed from Puerto Rico. On April 2nd, they sighted land, which they named Florida. The exact location of this landing is still debated. Some believe it was near present-day St. Augustine, while others argue for Melbourne Beach. After exploring the area, the fleet ventured further south. Leon navigated through the Florida Keys and then up the West coast of Florida. After eight months, he returned to Puerto Rico.

In Spain, Ponce de Leon was hailed as a hero and given another charter to explore Florida further. He sailed with a new fleet in 1515. However, when King Ferdinand died, the exploration was cut short.

In 1521, Ponce de Leon led another expedition to Florida, this time with the aim of settling the land. They arrived at the mouth of the Caloosahatchee River, where they faced an attack by the Calusa Indians. Leon was wounded by a poisoned arrow during the skirmish. He succumbed to his injuries, marking the end of that expedition. Over the years, a story has emerged suggesting Leon was in search of the mythical Fountain of Youth. However, this tale appears to lack historical evidence.